Use of oral glucocorticoids and risk of cardiovascular and. But these drugs also carry a risk of various side effects. Because oral corticosteroids affect your entire body instead of just a particular area, this route of. Ple, showed that a short course of oral steroids was associated with an increased risk of sepsis. (relative risk [rr] = 5. Management frequently comprises conservative treatment, including nasal saline irrigations, a combination of topical and oral corticosteroids
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